Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia

Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia

Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients' series. Patients and Methods. We studied 143 CLL patients of which 18 were symptomatic and needed treat...

[Prognostic significance of serum immunoglobulins in chronic lymphocytic leukemia].

-CLL is frequently accompanied by decreased levels of serum immunoglobulins which increases patients susceptibility to infections (1,2). Low levels of IgA, IgM and IgG occur in 30%, 30% and 10% of B-CLL patients respectively at the time of diagnosis. The appearance of decreased levels of immunoglobulins is a continuos process developing spontaneously during the untreated course of the disease. ...

Monoclonal and polyclonal serum free light chains and clinical outcome in chronic lymphocytic leukemia.

Free light chains (FLCs) are the most commonly detected paraproteins in chronic lymphocytic leukemia (CLL). We examined the types of FLC abnormalities and prognostic utility of the FLC assay compared with standard prognostic biomarkers in a prospective cohort of 339 patients with newly diagnosed CLL. Three types of FLC abnormalities were identified: monoclonal elevated FLC (elevated κ and/or λ ...

Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance

The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia.

Identification of patients at risk of early disease progression is the mainstay of tailored management in chronic lymphocytic leukemia (CLL). Although application of established biomarkers is limited by intrinsic detection/readout complexities, abnormality of κ and λ serum-free light chain ratio [sFLC (κ/λ)] was proposed as a straightforward prognosticator in CLL. By analyzing 449 therapy-naive...